Lesions of prefrontal cortex reduce attentional modulation of neuronal responses and synchrony in V4

Georgia G Gregoriou, Andrew F Rossi, Leslie G Ungerleider, Robert Desimone. Nature neuroscience, Jun 2014.

Abstract

It is widely held that the frontal eye field (FEF) in prefrontal cortex (PFC) modulates processing in visual cortex with attention, although the evidence that it is necessary is equivocal. To help identify critical sources of attentional feedback to area V4, we surgically removed the entire lateral PFC, including the FEF, in one hemisphere and transected the corpus callosum and anterior commissure in two macaques. This deprived V4 of PFC input in one hemisphere while keeping the other hemisphere…