A ubiquitous spectrolaminar motif of local field potential power across the primate cortex

Diego Mendoza-Halliday, Alex J. Major, Noah Lee, Maxwell Lichtenfeld, Brock Carlson, Blake Mitchell, Patrick D. Meng, Yihan (Sophy) Xiong, View ORCID ProfileJacob A. Westerberg, View ORCID ProfileAlexander Maier, Robert Desimone, Earl K. Miller, André M. Bastos. bioRxiv, Mar 2023.


The mammalian cerebral cortex is anatomically organized into a six-layer motif. It is currently unknown whether a corresponding laminar motif of neuronal activity exists across the cortex. Here, we report such a motif in the power of local field potentials (LFP). We implanted multicontact laminar probes in five macaque monkeys and recorded activity across layers in 14 cortical areas at various hierarchical processing stages in all cortical lobes. The anatomical laminar locations of recordings were histologically identified via electrolytic lesions. In all areas, we found a common spectrolaminar pattern characterized by an increasing deep-to-superficial layer gradient of gamma frequency LFP power peaking in layers 2/3, and an increasing superficial-to-deep gradient of alpha-beta power peaking in layers 5/6. Our results show an electrophysiological dissociation between superficial and deep layers that is preserved across the cortex, suggesting a ubiquitous layer and frequency-based mechanism for cortical computation.