Opportunities and challenges in modeling human brain disorders in transgenic primates

Charles G Jennings, Rogier Landman, Yang Zhou, Jitendra Sharma, Julia Hyman, J Anthony Movshon, Zilong Qiu, Angela C Roberts, Anna Wang Roe, Xiaoqin Wang, Huihui Zhou, Liping Wang, Feng Zhang, Robert Desimone, Guoping Feng. Nature neuroscience, Aug 2016.


Molecular genetic tools have had a profound impact on neuroscience, but until recently their application has largely been confined to a few model species, most notably mouse, zebrafish, Drosophila melanogaster and Caenorhabditis elegans. With the development of new genome engineering technologies such as CRISPR, it is becoming increasingly feasible to apply these molecular tools in a wider range of species, including nonhuman primates. This will lead to many opportunities for brain research, but…